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KMID : 1013220090070010023
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Jouranl of the Korean Society of Clinical Toxicology
2009 Volume.7 No. 1 p.23 ~ p.25
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A Case of Seizure in Diphenhydramine Overdose
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Park Jung-Soo
Kim Hoon
Lee Seok-Woo
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Abstract
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A 21-year-old woman ingested 1,250 mg of diphenhydramine in a single overdose. Diphenhydramine, a rare ingredient in over-the-counter medication, is used to treat insomnia in Korea. Toxicity is usually limited to anticholinergic symptoms. The standard approach to therapy for the treatment of diphenhydramine overdose is supportive care, including physostigmines and sodium bicarbonates. Here, we review the literature and for the first time report a case of acute diphenhydramine overdosage in Korea, complicated with seizures.
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KEYWORD
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Diphenhydramine, Seizure, Physostigmine, Poisoning
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